| 英文摘要 |
We report the case of a 57-year-old woman patient with the underlying of Huntington's disease (HD), which was diagnosed at her age of 50 years based on the findings of motor symptoms and positive genetic test. She had received tetrabenazine 25 mg per day regularly after the diagnosis. Her premorbid personality was extroverted, and had good job performance. A few months before her diagnosis of HD in 2012, she had a first depressive episode without obvious stress. She showed persistent low mood, social withdrawal, insomnia, and loss of energy. She had mild impaired work performance and memory, requiring help in daily functions. Her depressive mood was partially improved after 3–4 years without complete remission. In 2016, her mood was lifted – displaying grandiose thoughts, a decreased need for sleep, talkativeness, distractibility, and having goal-directed behaviors. She also had decreasing body weight. Moreover, she started to show psychotic symptoms such as grandiose and persecutory delusions at the end of 2017. In October 2018, she had above manic and psychotic symptoms, along with emotional lability, visual hallucinations, and reckless behaviors. She even presented herself with violence and self-harm behaviors because of her delusions. She did not visit any psychiatric clinic before admission. |
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