接種季節流感疫苗後的保護效力與抗體減退之探討

Vaccine effectiveness and antibody waning after season influenza vaccine injection

接種流感疫苗是預防流感最有效的方式，尤其是流感重症好發族群如嬰幼兒、孕婦、老年人、慢性病人、免疫功能不全者、肥胖等，更應接種流感疫苗來減少重症的產生。然而年紀、是否存在共病、接種疫苗類型、之前是否有接種流感疫苗、接種後抗體消退、群體免疫等因素也皆會影響流感效力。其中接種後抗體消退與疫苗保護效力息息相關。各病毒株抗體消退速度並不一致，在高齡的成年人有較快消退速度，進而減弱流感疫苗的保護效力。這議題值得進一步研究探討，並尋求解決之道。（感控雜誌2020:30:）

Receiving season influenza vaccine is the most effective method to prevent influenza disease, especially for high-risk individuals who are at increased risk for complications including death. Many factors may impact the immune response of season influenza vaccine. Matching the circulating influenza strains or not is important for protection effect of season influenza vaccine. However, vaccine effectiveness and antibody waning after season influenza vaccine administration is also an interesting issue to discuss and resolve.