| 中文摘要 |
本研究以黄芩（Scutellaria baicalensis Georgi）為素材探討抗發炎作用，作為緩解或消除發炎對生物體造成的傷害，以維護健康所提出之研究，亦對黃芩在傳統醫學應用之安全性彙整。另以黃芩萃取物為材料，分析在培養的動物細胞株中，對於發炎反應相關的三種因子之抑制功效進行探討，包括介白素6（interleukin 6）、一氧化氮（nitric oxide）、腫瘤壞死因子-α（TNFα），並進行細胞毒性（MTT）分析。結果顯示黃芩粉水萃液對於受到細菌脂多醣（Lipopolysaccharide）活化的巨噬細胞株具顯著抗發炎反應，可抑制LPS所誘發IL-6與NO之生成，對於IL-6之抑制率為81.6%，對NO之抑制率為47.8%，而對TNF-α生成則無顯著作用，在上述測試濃度皆未測得細胞毒性。綜上所述，黃芩於傳統經驗及細胞層面研究皆呈正面功效，雖然如此，對於其整體的臨床治療效果，仍需要有更多高質量的相關研究，期能明確支持黃芩於健康管理應用之建議。
This study focuses on the health benefits of a traditional herbal remedy, Scutellaria baicalensis Georgi, with emphasis on anti-inflammatory effects of the herbal extracts with a cell-based experimental model. Scutellaria baicalensis distributes in China, Russia, Mongolia, Korea, Japan and Taiwan. Numerous traditional uses of Scutellaria baicalensis are reviewed in this article. The health benefits of Scutellaria baicalensis includes anti-infection, anti-cancer, hepatitis, and high blood pressure. RAW 264.7 cell line, a mouse macrophage cell line, was employed to evaluate the anti-inflammatory activity of the extract of Scutellaria baicalensis. The results showed that the aqueous extract could significantly inhibit the production of the interleukin-6 (IL-6) and nitric oxide (NO), two pro-inflammatory mediators, induced by bacterial polysaccharide LPS. The inhibition rates for IL-6 and NO production were 81.6% and 47.8%, respectively. However, no inhibitory effect on the tumor necrosis factor-alpha (TNF-α) production was observed. Cytotoxicity assay also showed that the Scutellaria baicalensis extract exhibited little cytotoxicity to the macrophage cells. Further scientific studies are still needed in order to provide recommendations of using Scutellaria baicalensis for health and safety management. |
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