余甘子對抗發炎功效之探討

The Function of Phyllanthus Emblica on Anti-Inflammatory

余甘子Phyllanthus emblica L.（同義詞Emblica officinalis）在印度通常被稱為印度聖果或印度醋栗（Amla, Emblica officinalis Gaertn, Indian Gooseberry）。在阿育吠陀（印度的傳統醫學）中被廣泛用作食用（補品）植物及其治療之應用。本文綜述說明余甘子提取物（Phyllanthus Emblica Extract,PE）對於人類相關疾病，其有效性與緩解等相關研究整理，並對此醫學醫療民族藥用，提供安全性和毒性信息之整理。依據先前研究余甘子的各種功效潛力，包括抗微生物、抗氧化、鎮痛、解熱、保肝、抗腫瘤和抗潰瘍等等之活性，本研究綜合整理余甘子的證據表明，有希望作為人類疾病相關危險因素的有效性緩解物質之提供，並以台灣產地的余甘子提取物，對發炎反應相關細胞激素生成調節活性進行測試，分析在培養的巨噬細胞中，以人類常見的三種發炎相關因子生成量變化，包括一氧化氮（nitric oxide, NO）、介白素6（cytokine interleukin 6, IL-6）、腫瘤壞死因子（tumor necrosis factor, TNF），以及進行毒性分析。結果顯示，台灣產地的余甘子提取物對於受到細菌脂多醣（Lipopolysaccharide, LPS）活化的巨噬細胞株具有抗發炎作用，可抑制LPS所誘發之NO生成量39.4%、抑制LPS誘發之IL-6生成量18.2%；但是對抑制LPS所誘發之TNF-α生成則無作用，同時，受測細胞並無毒性。本研究結果可提供其潛在用途的健康管理之參考。
Phyllanthus emblica L. (synonym Emblica officinalis) is commonly referred to as the Indian fruit or Indian gooseberry. Among Ayurveda (traditional Indian medicine), P. emblica is widely used as an edible (tonic) plant and the application of disease treatment. For previous studies in this kind of field, it was found that Phyllanthus Emblica (PE) is effective in the treatment of human-related diseases and symptoms, and the safety and toxicity of this herb are also fully discussed. According to previous studies found that P. emblica possess various pharmacological effects, including anti-microbial, anti-oxidation, analgesic, antipyretic, liver-protecting, antitumor and anti-ulcer. And it can be e a human disease relief substance. This study tested the inflammatory response-related cytokine production-regulating activity of PE in Taiwan, and analyzed the changes of three common inflammatory factors, including nitric oxide (NO), cytokine interleukin 6 ( IL-6), tumor necrosis factor (TNF) of their toxicity analysis. The results showed that PE in Taiwan has anti-inflammatory effects on macrophage cell line activated by lipopolysaccharide (LPS). It can inhibit 39.4% of NO, and inhibit LPS of its IL-6 reach18.2%; but no effect on inhibiting of TNF-α. At the same time, no toxicity was found in the cells tested. Nonetheless, there is a need for more high-quality related research on the therapeutic effects of PE to provide recommendations for health management for its potential use.