治療性疫苗與免疫療法分述與婦癌使用概況

Immunotherapy in gynecological cancer

婦科癌症根據不同癌症類型，大多選擇手術、化學治療、或是放射治療等不同治療方式，然而對於病人存活率以及復發率，似乎沒有明顯的突破，隨著免疫學與腫瘤細胞關聯之研究增加，如何使用免疫療法於婦科癌症之治療，成為未來發展之趨勢。

Traditional gynecological cancer treatment includes surgery, chemotherapy and radiotherapy. However, for advanced and metastatic cancer, these treatments have limitation in prognosis. Recently, immunotherapy has been developed. In gynecological cancer, human papillomavirus infection (HPV)-related cervical, vulvar and vaginal cancer, therapeutic vaccine may improve the response for these HPV-related cancers. In addition, other immune stimulators for T-cells may also provide efficacious cancer treatment. Herein, we introduce current immunotherapies, including therapeutic anti-cancer vaccines, oncolytic viruses, immunostimulatory cytokines, adoptive cell transfer, tumor-targeting mAbs, and bispecific T-cell engager. Then, we also describe the immunotherapy in gynecological cancer treatment.