This case report describes the nursing experience of a 65-year-old man with occurring bowel obstruction as a result of colorectal cancer. During the nursing period, which lasted from March 7th, 2018 to March 20th, 2018, the patient underwent accepted emergency surgery to deal with physical symptoms and psychological impacts. According to the data that was analyzed with the assessment tool of Gordon’s 11 functional health patterns, the result indicated that the patient’s nursing problems were potential risks of infection, acute pain, and anxiety. Throughout the caring period, various methods were provided to help alleviate patient’s pain, including teaching semi-sitting posture to relax the abdominal muscle contractions, adjusting the drainage tube to avoid being pulled, assisting on coughing and changing position pressure on the pulled muscle with wound. Distraction techniques were also given to help ease the pain, such as encouraging patients to speak their thoughts and feelings as well as explaining their concerns, and thus providing knowledge regarding disease and treatment that would enhance their insight. In addition to wound cares, the provider also contacted social workers and discharge planning staffs to accommodate financial and home care assistance to reduce the patient’s anxiety. This nursing experience illustrates the necessity of cross-disciplinary teamwork in whole-person care, in addition to the professional nursing judgment and nursing intervention, which would be helpful to other nurses that’s caring patients with similar situation. Hence, on top of the nursing assessment and appropriate interventions, in order to provide holistic care, multidisciplinary cooperation is essential.