Four full-scale masonry panels in reinforced concrete(RC) frames were tested to investigate the influence of the opening and the type of masonry panel on in-plane seismic behavior. Test parameters of specimens were the construction method and the opening condition. Confined masonry panels failed in diagonal tension and infilled masonry panels failed in bed-joint sliding. Columns of specimens without opening failed in shear, and independent columns of specimens with openings showed flexural behavior. Behavior of both columns and panels and the interaction between columns and panels are affected by the opening condition and the construction method. The maximum strength and initial stiffness is higher for confined specimens and specimens without opening, and the maximum displacement has the opposite trend.