This paper investigates the responses of buried pipelines under large fault movements using numerical models and small-scale experiments. Well-designed small-scale shear boxes experiments can induce the soil-pipeline interaction under fault displacements. Numerical models built by the ABAQUS commercial software were able to simulate the behavior of small-scale shear box experiments at different soil depths. Comprehensive and reliable numerical simulation of this problem requires experimental data to calibrate and verify the three dimensional responses of pipelines subjected to axial and flexural loadings. Finally, recommendations and future works are proposed for the design of small-scale experiments and numerical models.