A structural health monitoring(SHM) mobile module based on bioinformatics is studied in this paper. An eight-story down-scale steel building located at the shaking table of the National Center for Research on Earthquake Engineering(NCREE) was used as the testing benchmark structure. In order to create a mobile SHM prototype as well as providing a platform for application on future control system, the system was developed by utilizing both advanced software and hardware in the related field.