Scour failures tend to occur suddenly and without warning. Hydraulic scour is one of the major factors in bridge failure. Bridges that are subject to periodic flooding should be monitored during these periods for the safety of the traveling public. The wireless sensor network has been applied widely and in various fields. In this paper, the micro-electro-mechanical system(MEMS) pressure sensor is integrated with the wireless Zigbee network on a sensor board for real-time bridge scour monitoring. A wireless MEMS scour monitoring system was developed and tested in the laboratory. The proposed wireless MEMS scour monitoring system can measure the scouring and deposition processes as well as the variations of the water level at the bridge piers. Experiments were conducted in a flume to demonstrate the applicability of the system. The results indicate that the proposed system has the potential to monitor scour evolution in the field.