Comparison of Insight in Patients with Schizophrenia, Bipolar I Disorder, and Major Depressive Disorder in a Real-world Setting

Comparison of Insight in Patients with Schizophrenia, Bipolar I Disorder, and Major Depressive Disorder in a Real-world Setting

Objective: In this study, we intended to compare the insight in patients with schizophrenia (SCH), bipolar I disorder (BD), and major depressive disorder (MDD). Methods: This cross-sectional study was conducted from December 2017 to July 2018. We recruited 102 patients with SCH (n = 55), BD (n = 25), and major depression (n = 22) to assess insight with the Taiwanese version of Self-Appraisal of Illness Questionnaire (SAIQ), and to test the differences of those patient groups. Results: Patients with SCH had a significantly lower average SAIQ score compared with MDD (25.95 ± 9.70 vs. 36.38 ±7.75, p ＜ 0.01), but no significant difference existed in patients between the SCH and bipolar disorder. For the SAIQ worry subscale, patients with SCH (p ＜ 0.05) and those with bipolar disorder (p ＜ 0.01) had significant lower scores than those with major depression. For the need for treatment subscale, patients with SCH had significantly lower scores than those with bipolar disorder (p ＜ 0.05) and those with major depression (p ＜ 0.05). For the presence/outcome of illness subscale, patients with SCH had significant lower scores than those with bipolar disorder (p ＜ 0.01) and those with major depression (p ＜ 0.001). Conclusion: Patients with SCH had lower total insight as well as individual domain than patients with MDD. Patients with SCH had poorer insight than those with bipolar disorder in need for treatment and presence/outcome of illness, but not in the worry subscale. The significant difference in patients with BD and those with major depression were on the worry domain.