| 英文摘要 |
Background and Purpose: A randomized, double-blind, placebo-controlled human trial was conducted to investigate the effects of carnitine drink on obesity in obese subjects in Taiwan. Methods: Fifty subjects with simple obesity and body mass index(BMI)≧27(or >30% body fat) who engaged in aerobic exercise for 2–4h weekly were recruited. The subjects were randomly assigned to receive either carnitine drink or placebo, once daily, for 6 consecutive weeks. Body weight, body fat, and biochemical indicators(i.e., blood glucose, blood lipids, albumin, serum creatinine, blood urea nitrogen, glutamic oxalacetic transaminase(GOT), and glutamic-pyruvate transaminase(GPT)) were measured every 3 weeks. Subsequently, magnetic resonance imaging was conducted to examine the distribution and thickness of abdominal fat and the results were used to determine the effects of carnitine drink on body fat. Results: A total of 28 subjects completed the study. Six weeks of consumption of carnitine drink led to 0.7% and 2.1 kg reductions in body fat and body weight, respectively, compared with the placebo group. In addition, cholesterol level was reduced by 3.8%. No severe adverse effects were observed. Conclusions: Intake of carnitine drink is effective for reducing body weight and cholesterol in obese subjects. |
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