| 英文摘要 |
Foods and drinks have been adulterated with illicit drugs to facilitate criminal activities.Unfortunately, conventional analytical methods are incapable of rapidly characterizingthese drugs in samples, as serious interferences from sample matrices must be removedthrough tedious and time-consuming pretreatment. Ambient ionization mass spectrometry(AMS) generally does not require sample pretreatment and is thus a suitable tool fordirectly and rapidly detecting illicit drugs in samples in different physical states. In thisstudy, thermal desorption electrospray ionization mass spectrometry (TD-ESI/MS), an AMStechnique, was utilized to efficiently characterize illicit drugs spiked in samples includingdrinks, powders, and jelly candies. To perform sensitive analysis, the mass analyzer wasoperated in multiple reaction monitoring mode to monitor the molecular and fragmentions of the target analytes. The time required to complete a typical TD-ESI/MS analysis wasless than 30 s. The limits of detection (LODs) for illicit drugs were found to be 100 ppb indrinks, 100e1000 ppb in instant powders, and 1.3e6.5 ng/mm2 on stamp surfaces. FM2 andnitrazepam laced in the inner layer of a jelly candy were detected by TD-ESI/MS, showcasingthe advantage of the technique for direct and rapid analysis as opposed to conventionalmethods. |
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