| 英文摘要 |
The study aimed to analyze the incidence of acute hepatitis B (AHB) and the risk factors of hepatitis B virus (HBV) infection in HBV vaccinated birth cohorts from 1998 to 2017 in Taiwan. The results showed that the continuing downward trend of AHB incidence were in all age groups, especially the age between 15 and 29 years old (85.5%). In HBV vaccinated birth cohorts the majority AHB confirmed cases were 88% for age less than 1 year and age between 15 and 29 years. The risk factors might include perinatal HBV infection, iatrogenic infection risk, unprotected sex, etc. The universal hepatitis B vaccination program has effectively reduced the occurrence of AHB in Taiwan. A previous study demonstrated the surface antigen carriage rate at age six decreased to around 0.8% in Taiwan. However, we observed the continuing downward trend of AHB incidence. In addition, the vaccine coverage rate was reached to 95%. In conclusion, this study suggested that there may not be urgent to consider booster HBV vaccination campaign for the HBV vaccinated birth cohorts. In order to reduce the HBV transmission, it still needs to keep surveillance of the trend of AHB and ensure the implementation of public health interventions. |
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