月旦知識庫
 
  1. 熱門:
 
首頁 臺灣期刊   法律   公行政治   醫事相關   財經   社會學   教育   其他 大陸期刊   核心   重要期刊 DOI文章
中醫藥研究論叢 本站僅提供期刊文獻檢索。
  【月旦知識庫】是否收錄該篇全文,敬請【登入】查詢為準。
最新【購點活動】


篇名
牛膝改善大鼠學習記憶障礙之研究
並列篇名
The Study of Achyranthes Bidentata on Learning and Memory Impairment in Rats
作者 吳龍源呂峻安吳啟瑞蔡汎修蔡金川林立偉
中文摘要
背景:阿茲海默症主要臨床症狀為記憶能力喪失,其病理特徵為老年斑,而老年斑主因類澱粉樣蛋白(amyloid β-peptide)沉積所致,基於此理論本實驗設計應用amyloid β peptide (Aβ1-40)來誘發阿茲海默症學習障礙之動物模型,並以水迷宮來評估中藥牛膝改善學習記憶障礙的作用。材料&方法:本計畫以80%乙醇及水進行藥材萃取及分離,分別提取純化而製得懷牛膝皂苷提取物(ABS)及懷牛膝多醣體提取物(ABP);後進行對Aβ1-40誘導大鼠記憶障礙改善作用之評估。結果:Aβ1-40可造成大鼠於水迷宮之操作障礙暨短期記憶與參考記憶之障礙。ABS於50 mg/kg可改善Aβ1-40側腦室輸注所導致水迷宮空間操作暨參考記憶能力之障礙;而ABP於100 mg/kg也能改善Aβ1-40側腦室輸注所導致水迷宮空間操作暨參考記憶能力之障礙。結論:懷牛膝之成分ABS及ABP能改善Aβ1-40誘導大鼠水迷宮學習記憶障礙,可供中醫藥臨床基礎研究參考。 Purpose: Alzheimer’s disease (AD) is characterized by neuropathological hallmarks such as senileplaque and neurofibrillary tangles caused by the amyloid β peptide (Aβ1-40). For this reason, we demonstratedthe role of the improve effect of Achyranthesbidentata against continuous intracisternal injection of Aβ1-40 in rats Materials & Methods: This present result obtained total saponins and total polysaccharides extracted from Actyranthes bidentate (ABS and ABP) by 80% ethanol and distilled water. We further investigated the effects of ABS and ABP on the memory function caused by Aβ1-40 in rats. Intracisternal injection of Aβ1-40 caused the dysfunction of memory function on water maze Results: Pretreatment with ABS at a dosage of 50 mg/kg or ABP at 100 mg/ kg reversed the dysfunction of memory function on water maze caused by intracisternal injection of Aβ1-40. Conclusions: ABS and ABP can improve the learning and memory impairment of rat water maze induced by Aβ1-40, which can be used as a reference for clinical basic research of traditional Chinese medicine.
英文摘要
Purpose: Alzheimer’s disease (AD) is characterized by neuropathological hallmarks such as senileplaque and neurofibrillary tangles caused by the amyloid β peptide (Aβ1-40). For this reason, we demonstratedthe role of the improve effect of Achyranthesbidentata against continuous intracisternal injection of Aβ1-40 in rats Materials & Methods: This present result obtained total saponins and total polysaccharides extracted from Actyranthes bidentate (ABS and ABP) by 80% ethanol and distilled water. We further investigated the effects of ABS and ABP on the memory function caused by Aβ1-40 in rats. Intracisternal injection of Aβ1-40 caused the dysfunction of memory function on water maze Results: Pretreatment with ABS at a dosage of 50 mg/kg or ABP at 100 mg/ kg reversed the dysfunction of memory function on water maze caused by intracisternal injection of Aβ1-40. Conclusions: ABS and ABP can improve the learning and memory impairment of rat water maze induced by Aβ1-40, which can be used as a reference for clinical basic research of traditional Chinese medicine.
起訖頁 1-8
關鍵詞 類澱粉樣蛋白阿茲海默症水迷宮牛膝amyloid β peptideAlzheimer’s diseasewater mazeActyranthes bidentate
刊名 中醫藥研究論叢  
期數 201809 (21:2期)
出版單位 臺北市中醫師公會
該期刊-下一篇 中醫藥輔助治療化療不適後生活品質改善與用藥模式比較探討──乳癌住院患者前瞻式單臂世代研究
 

新書閱讀



最新影音


優惠活動




讀者服務專線:+886-2-23756688 傳真:+886-2-23318496
地址:臺北市館前路28 號 7 樓 客服信箱
Copyright © 元照出版 All rights reserved. 版權所有,禁止轉貼節錄