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篇名
Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acidinduced animal models of inflammation
並列篇名
Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acidinduced animal models of inflammation
作者 Pai-An Hwang (Pai-An Hwang)Yu-Lan Hung (Yu-Lan Hung)Shih-Yung Chien (Shih-Yung Chien)
英文摘要
Sargassum hemiphyllum is a common plant found on the coasts of Taiwan; it has been used as an anti-inflammatory agent in traditional herbal medicine. This study aimed to evaluate the anti-inflammatory effects of S. hemiphyllum sulfated polysaccharide (SHSP) using two different mouse models. In both arachidonic acid-induced ear inflammatory gavage and paint models, SHSP decreased ear swelling and erythema. In addition, SHSP decreased the production of myeloperoxidase, nitric oxide, interleukin-1b (IL-1b), IL-6, and tumor necrosis factor-a in a dose-dependent manner. Histological examination results showed that SHSP reduced the area of neutrophilic infiltration in inflamed ears. The anti-inflammatory activity of SHSP has already been demonstrated in vitro. In this study, SHSP extracted from the same species of brown seaweed exhibited anti-inflammatory activity in both oral and topical applications in vivo. Therefore, SHSP may play a role in the treatment of inflammatory diseases.
起訖頁 49-56
關鍵詞 animal modelanti-inflammationcytokinesmyeloperoxidaseSargassum hemiphyllum
刊名 JOURNAL OF FOOD AND DRUG ANALYSIS  
期數 201501 (23:1期)
出版單位 衛生福利部食品藥物管理署
該期刊-上一篇 Characterization and determination of antioxidant components in the leaves of Camellia chrysantha (Hu) Tuyama based on compositioneactivity relationship approach
該期刊-下一篇 Antioxidant and antiacetylcholinesterase activities of Sorbus torminalis (L.) Crantz (wild service tree) fruits
 

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