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篇名
Tetrodotoxin and paralytic shellfish poisons in gastropod species from Vietnam analyzed by highperformance liquid chromatography and liquid chromatographyetandem mass spectrometry
並列篇名
Tetrodotoxin and paralytic shellfish poisons in gastropod species from Vietnam analyzed by highperformance liquid chromatography and liquid chromatographyetandem mass spectrometry
作者 Hsiao-Chin Jen (Hsiao-Chin Jen)Thi Anh-Tuyet Nguyen (Thi Anh-Tuyet Nguyen)Ya-Jung Wu (Ya-Jung Wu)Tung Hoang (Tung Hoang)Osamu Arakawa (Osamu Arakawa)Wen-Feng Lin (Wen-Feng Lin)Deng-Fwu Hwang (Deng-Fwu Hwang)
英文摘要
Among marine toxins, tetrodotoxin (TTX) and paralytic shellfish poisons (PSPs) are known as notorious neurotoxins that induce serious food poisoning incidents in the Southeast Asia region. The aim of this study was to investigate whether TTX and PSP toxins are important issues of seafood safety. Paralytic toxicity was observed in mice exposed to 34 specimens from five species of gastropods using a PSP bioassay. Five species of gastropods, Natica vitellus, Natica tumidus, Oliva hirasei, Oliva lignaria, and Oliva annulata, were collected from the coastal seawaters in Nha Trang City, Vietnam, between August 2007 and October 2007. The average lethal potency of gastropod specimens was 90 40 (mean standard deviation) mouse units (MU) for N. vitellus, 64 19 MU for N. tumidus, 42 28 MU for O. hirasei, 51 17 MU for O. lignaria, and 39 18 MU for O. annulata. All toxic extracts from the sample species were clarified using a C18 Sep-Pak solid-phase extraction column and a microcentrifuge filter prior to analysis. High-performance liquid chromatography coupled with fluorescence detection indicated that the toxins of the olive shell (O. hirasei, O. lignaria, and O. annulata) were mainly composed of saxitoxin (STX) (73e82%), gonyautoxin (GTX) 2, 3 (12e22%), and minor levels of TTX (5e6%). The toxins of N. vitellus and N. tumidus were mainly composed of STX (76e81%) and GTX 1, 4 (19e24%). Furthermore, liquid chromatographyetandem mass spectrometry analysis was used to verify the identity of the PSPs and TTX. Our evidence shows that these gastropods have novel toxin profiles.
起訖頁 178-188
關鍵詞 High-performance liquid chromatography coupled with fluorescence detectionLiquid chromatographyetandem mass spectrometryParalytic shellfish poisonTetrodotoxin
刊名 JOURNAL OF FOOD AND DRUG ANALYSIS  
期數 201404 (22:2期)
出版單位 衛生福利部食品藥物管理署
該期刊-上一篇 Analysis of drug abuse data reported by medical institutions in Taiwan from 2002 to 2011
該期刊-下一篇 Analysis of iodine content in seaweed by GC-ECD and estimation of iodine intake
 

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