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篇名
Autophagy in drug-induced liver toxicity
並列篇名
Autophagy in drug-induced liver toxicity
作者 Si ChenWilliam B. Melchior Jr. (William B. Melchior Jr.)Yuanfeng Wu (Yuanfeng Wu)Lei Guo (Lei Guo)
英文摘要
Liver injury resulting from exposure to drugs and chemicals is a major health problem. Autophagy is an important factor in a wide range of diseases, such as cancer, liver disease, muscular disorder, neurodegeneration, pathogen infection, and aging, and emerging evidence indicates that autophagy makes a substantial contribution to the pathogenesis of drug- and chemical-induced liver toxicity. In this review, we summarize current knowledge on autophagy triggered by toxicants/toxins, the protective role of autophagy in liver toxicity, and the underlying molecular mechanisms. We also highlight experimental approaches for studying autophagy.
起訖頁 161-168
關鍵詞 autophagydrug-induced liver toxicity
刊名 JOURNAL OF FOOD AND DRUG ANALYSIS  
期數 201404 (22:2期)
出版單位 衛生福利部食品藥物管理署
該期刊-下一篇 Analysis of drug abuse data reported by medical institutions in Taiwan from 2002 to 2011
 

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