磷酸烯醇丙酮酸：糖類的磷酸轉移系統在細菌感染所扮演的角色

The Roles of Phosphoenolpyruvate: Sugar Phosphotransferase System (PTS) in Bacterial Infection

Bacteria uptake nutrients from the environment via a variety of systems. The phosphoenolpyruvate:sugar phosphotransferase system (PTS) catalyzes the transport and phosphorylation of sugars or sugar derivatives into cytoplasm. The basic components of PTS are enzyme I (EI), HPr and enzyme II (EII) complex. The phosphoryl group is transferred between these components and finally to the corresponding sugar (carbohydrate). In addition to carbohydrate transportation, PTS regulates vast number of cellular processes. In this mini-review, we will describe the effects of PTS components on bacterial virulent factors, biofilm formation, bacterial resistance to antimicrobial agent and mouse infection model. 細菌利用不同的系統吸取環境中的養分，其中，磷酸烯醇丙酮酸：糖類的磷酸轉移系統（PTS）可讓細菌迅速吸取糖類並將其磷酸化，以便進入後續的代謝路徑。PTS基本上包括酵素I（enzyme I），HPr和酵素II複合物（enzyme II complex）。隨著對PTS的研究越來越深入和廣泛，科學家也發現PTS在細菌感染扮演重要的角色，包括PTS影響細菌毒素因子的表現，生物膜的形成，抗藥性，以及在老鼠感染模式上的差異。