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篇名
Phosphorylation and antiaging activity of polysaccharide from Trichosanthes peel   全文下載 全文下載
並列篇名
Phosphorylation and antiaging activity of polysaccharide from Trichosanthes peel
作者 Min Zhang (Min Zhang)Nana Su (Nana Su)Qianli Huang (Qianli Huang)Yufen Wang (Yufen Wang)Jinglei Li (Jinglei Li)Ming Ye (Ming Ye)
英文摘要
Polysaccharides from Trichosanthes peel (TPP) were obtained by ultrasound-assisted extraction. TPP-1 was separated from the TPP by Sephadex G-100 column chromatography. Phosphorylation of TPP-1 was carried out and phosphorylated TPP-1 was named as PTTP-1. The results of infrared spectra, 13C nuclear magnetic resonance spectra and 31P nuclear magnetic resonance spectra showed that the main structure of PTPP-1 was similar to that of TPP-1 and -H2PO3 groups which were conjugated to C-6 of/4)-a-D-Manp-(1/, C- 4 of/6)-a-D-Galp-(1/, C-2 and C-3 of/1)-a-L-Araf, C-2 of/1)-a-L-Araf-(3/, and C-6 and C-3 of /1)-a-D-Glcp. In vivo antiaging activity results proved that TTP-1 and PTTP-1 could both significantly improve the body weight, spleen index, and thymus index of the Dgalactose- induced aging mice, increase the levels of superoxide dismutase, catalase, glutathione peroxidase, and reduce malondialdehyde contents in the liver, brain, and serum of aging mice. These results indicated that both TPP-1 and PTTP-1 presented significant antiaging activity. Moreover, PTTP-1 showed stronger antiaging effects in aging mice, indicating that phosphorylation improved antiaging effect.
起訖頁 976-983
關鍵詞 antiaging activityphosphorylation modificationTrichosanthes peel polysaccharide
刊名 JOURNAL OF FOOD AND DRUG ANALYSIS  
期數 201710 (25:4期)
出版單位 衛生福利部食品藥物管理署
該期刊-上一篇 Exploration of ethyl anthranilate-loaded monolithic matrix-type prophylactic polymeric patch
該期刊-下一篇 Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides
 

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