以綠茶為大鼠唯一飲水來源可能與 Haloperidol 誘發運動障礙有關：與多巴胺代謝關係   全文下載

Injected Haloperidol-Induced Motor Deficits Are Potentiated in Rats Drinking Green Tea as a Sole Source of Water: Relationship with Dopamine Metabolism in the Caudate

抗精神病藥物haloperidol（HAL）廣泛用於治療神經精神失調，然而此療法會引發錐體外症候群（EPS），包括短期的帕金森氏症和晚期遲發性不自主運動併發症（TD）。這些不明原因的症狀造成此療法嚴重受限。有些研究指出，HAL代謝的氧化壓力與錐體外症候群的誘發有關。我們推測綠茶的抗氧化特性可能防止HAL誘發之錐體外症候群。本研究將綠茶萃取物（GTE）作為白化症雄性wistar大鼠唯一的飲水來源，檢驗其對於HAL誘發錐體外症候群的影響。我們發現飲綠茶萃取物與飲水的動物相較，HAL引起的運動障礙與晚期遲發性不自主運動併發症更加嚴重。飲綠茶萃取物動物的HAL誘發多巴胺量較飲水動物多，其多巴胺代謝濃度在nucleus accumbens較高，在caudate卻較低（p < 0.01）。飲綠茶萃取物與HAL誘發錐體外症候群有關，可能是因其增加高香草酸（HVA）和3,4-dihydroxy-phenylacetic acid（DOPAC）／多巴胺在caudate的比值。反之，綠茶萃取物增加多巴胺量，提高其在nucleus accumbens的代謝，可能在HAL療程中使精神分裂症復發。因此建議接受HAL治療的病人應避免飲用綠茶。"

The antipsychotic drug “haloperidol” (HAL) has been widely used for the treatment of a range of neuropsychiatric disorders. However treatment also induces extrapyramidal symptoms (EPS) including short term parkinsonism and late complication tardive dyskinesia (TD). These idiopathic symptoms are associated with serious limitations in this therapy. Some studies have suggested that oxidative stress induced during the metabolism of HAL is involved in the elicitation of EPS. We speculated if green tea may prevent HAL-induced EPS because of its antioxidant properties. In the present study, the efficacy of green tea extract (GTE) given as a sole source of water on HAL-induced EPS male albino wistar rats was examined. We found that HAL-induced motor deficits and elicitation of TD were more severe in GTE than water dinking animals. HAL-induced dopamine level was increased and its metabolites concentrations were higher in the nucleus accumbens and lower (p < 0.01) in the caudate of GTE-drinking than water-drinking animals. Increased ratios of homovanillic acid (HVA) and 3, 4-dihydroxyphenylacetic acid (DOPAC)/dopamine in the caudate may be involved in the precipitation of HAL-elicited EPS while drinking GTE. Conversely GTE increased the level of dopamine moreover raised its metabolites in the nucleus accumbens may relapsed the schizophrenic symptoms while on the treatment HAL. We thus suggest that patients on HAL therapy should avoid green tea.