三十八種精油的細胞毒性與抗血小板聚集活性及其化學成分分析   全文下載

Cytotoxicity, Anti-Platelet Aggregation Assay and Chemical Components Analysis of Thirty-Eight Kinds of Essential Oils

本研究使用38種精油，包括來自臺灣的4種高緯度的樹木，紅檜、臺灣杉、柳杉和扁柏，以及34種商業上經常使用的精油，進行對5種腫瘤細胞的細胞毒性測定及抗血小板聚集試驗測定。兩種常用的精油，香柏和檀香對腫瘤細胞表現出明顯的細胞毒性。此外，香蜂草和胡椒兩種精油對血小板凝集有中度抑制作用。精油之前曾被研究有細胞毒性，但此為第一次發現香柏和檀香對五種腫瘤細胞有明顯的細胞毒性。以我們所知，這也是精油對血小板凝集影響測試的第一份報告。

Thirty-eight essential oils (EOs), including 4 products from Taiwan high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function. Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. Some essential oils had been reported to contain cytotoxicity. However, the cytotoxicity of EOs from J. virginiana and S. album is revealed for the first time. To the best of our knowledge, this is the first report for anti-platelet aggregation effect of EOs.