補充紅甘藍菜汁增加小鼠血清中總抗體含量   全文下載

Supplementation of Red Cabbage (Brassica oleracea L. var.) Juice Increases Serum Total Antibody Levels in Mice

本研究探討在不同動物模式下分別補充紅甘藍菜汁8週及6週，對未致免及以雞卵白蛋白（ovalbumin, OVA）/complete Freund’s adjuvant（CFA）致免小鼠的影響，主要測定小鼠血清中免疫球蛋白IgA 、IgE 、IgG和IgM總抗體含量，及OVA-特異性IgE 、IgG1和IgG2a濃度的變化。結果顯示，無論在未致免及OVA/CFA致免模式下，補充紅甘藍菜汁不會顯著影響小鼠體重、飼料攝食及攝食效率，在OVA/CFA致免模式下，補充紅甘藍菜汁不會顯著影響血清中OVA-特異性抗體的濃度，但是補充紅甘藍菜汁則增加未致免小鼠血清總抗體的濃度，尤其是IgM及IgE。本研究結果推測，紅甘藍菜汁具有動物體內免疫調節活性，可增加未致免小鼠的體液免疫反應。"

This study investigates the effects of supplementing unimmunized (non-specific) and ovalbumin (OVA)/complete Freund’s adjuvant (CFA)-immunized mice with red cabbage (RC, Brassica oleracea L. var.) juice for 8 and 6 weeks, respectively. Changes in serum total immunoglobulin (Ig) A, IgE, IgG and IgM levels, as well as OVA-specific IgE, IgG1 and IgG2a titers were determined. The results showed that RC juice supplementation did not significantly affect the body weight, feed intake and feed efficiency in either unim-munized or OVA/CFA-immunized mouse models. Serum OVA-specific antibody titers in OVA/CFA-immunized mice were also not significantly affected. However, RC juice supplementation increased serum total antibody levels, especially IgM and IgE, in the sera of unimmunized mice. The present study suggests that RC juice has immunomodulatory effects in vivo via enhancing humoral immunity under unimmunized status.