鉬酸輔助茚三酮為基礎之含胺基藥物分析   全文下載

Molybdate Assisted Ninhydrin Based Sensitive Analytical System for the Estimation of Drugs Containing Amine Group

本文敘述一敏感的分光光度法，用於分析isoniazid 、lisinopril dihy-drate 、amoxicillin trihydrate 、ampicillin trihydrate 、glucosamine sulfate 、 phenylpropanolamine hydrochloride及gabapentin。分析方法基於藥物分子與?三酮和鉬酸鈉的混合物反應時，於最大最大吸收波長570 nm產生Ruhemann紫色物質。無論是同日內和異日間之分析統計，或是與其他已發表的方法比較，都顯示本方法精密度及準確度高，可成功地分析含胺基藥物製劑，並應用於品質管制。

A sensitive spectrophotometric method for the analysis of isoniazid, lisinopril dihydrate, amoxicillin trihydrate, ampicillin trihydrate, glucosamine sulfate, phenylpropanolamine hydrochloride and gabapentin is described. The analysis is based on the reac-tion of drug molecules with ninhydrin and sodium molybdate mixture to give Ruhemann’s purple product with maximum absor-bance (λmax) at 570 nm. The statistical analysis of intra-day and inter-day estimation of drugs as well as comparison with reported methods demonstrated high precision and accuracy of the proposed method. The method was successfully applied to the analysis of pharmaceutical preparations. The procedure was suitable for quality control application.