物化鑑定利用高壓均質法製備蛇床子素與羥丙基 -β- 環糊精的包埋物   全文下載

Physicochemical Characterizations of Osthole-hydroxypropyl-β-cyclodextrin Inclusion Complexes with High-Pressure Homogenization Method

本文目的在評估兩種製備蛇床子素與羥丙基-β-環糊精包埋物的方法，這兩種方法為酸鹼中和法及高壓均質法；所製備出來的包埋物將以示差熱分析儀、 傅立葉轉換紅外線光譜儀、粒徑測定儀與溶離試驗等方法檢測評估。從示差熱分析儀的圖譜分析，高壓均質法所製備出來的產物包埋效果比物理性混和及酸鹼中和法還更徹底；從傅立葉轉換紅外線光譜儀的圖譜顯示藥物與環糊精之間的鍵結關係，在粒徑測定中發現高壓均質法所製備出來的包埋物具有最小的平均粒徑，溶離測定的資料亦發現，高壓均質法所製備的包埋物其溶離速率比其他兩種來的更加快速。從所有實驗數據可得結論，以蛇床子素與羥丙基-β-環糊精包埋物為例，最佳的包埋物的製備技術為高壓均質法。

The purpose of this research was to evaluate the inclusion complex composed of osthole and hydroxypropyl-β-cyclodextrin (HP-β-CD) by using two preparative techniques, neutralization and high-pressure homogenization (HPH) method. The solid complexes were characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), particle size determination, and dissolution test. The DSC diagrams indicated that the solid complex from the HPH method led to more complete complexation than that of physical mixture and neutralization method. The formation of inclusion complex between drug and cyclodextrin (CD) was verified by FTIR analysis. The smallest mean particle size of solid complex was acquired from the HPH method. The results proved that the rate of drug release for the inclusion complex obtained from the HPH method was much faster than those of neutralization, physical mixture, HP-β-CD and osthole alone.