本文利用方波伏安法研究水性媒介物質中，降血脂藥物Pravastatin玻璃碳電極（GCE）及網版印刷碳電極（SPCE）之電有機氧化反應。pH 5.0緩衝液中，玻璃碳電極及網版印刷碳電極之最大電流強度分別為+1.3 V vs. AgCl/Ag及+1.0 V vs. Ag。研究結果顯示，此開發中的方法具有好的效能，檢體不需前處理，即可應用於Pravastatin藥劑之電氧化定量分析。比較分析此二種電極，網版印刷碳電極表面敏感度較高且不需清除電極表面即可重複運作，分析速度較不受限制。
英文摘要
The electrooxidative behavior of pravastatin (PRV) in aqueous media was studied by square-wave voltammetry at a glassy-carbon electrode (GCE) and at a screen-printed carbon electrode (SPCE). Maximum peak current intensities in a pH 5.0 buffer were obtained at +1.3 V vs. AgCl/Ag and +1.0 V vs. Ag for the GCE and SPCE surface respectively. Validation of the developed method-ologies revealed good performance characteristics and confirmed their applicability to the quantification of PRV in pharmaceutical products, without significant sample pretreatment. A comparative analysis between the two electrode types showed that SPCEs are preferred as an electrode surface because of their higher sensitivity and the elimination of the need to clean the electrode’s surface for its renewal, which frequently is, if not always, the rate-limiting step in voltammetric analysis.
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