以傅立葉轉換紅外光譜儀（FTIR）及衰減全反射式傅立葉紅外光譜儀（ATR-FTIR）短期監測Ranitidine 光降解過程   全文下載

Short Term Monitor of Photodegradation Processes in Ranitidine Hydrochloride Observed by FTIR and ATR-FTIR

本實驗利用傅立葉轉換紅外光譜儀（FTIR）及衰減全反射式傅立葉紅外光譜儀（ATR-FTIR），分析ranitidine hydrochloride 暴露在氧氣及波長310 nm 紫外光B（UVB）照射之風化箱（weathering chamber）中降解作用。衰減全反射式傅立葉紅外光譜儀（ATR-FTIR）數據顯示，降解作用有空間異質性。紫外光直接照射層才能偵測到顯著數量之光降解物，其主要的衰退或改變於出現既寬且廣訊號群，波數（wavenumber）3600-3200 cm-1 或/及3500-3400 cm-1 附近。本研究探討衰減全反射式傅立葉紅外光譜儀是否為觀察粉末物質表面最初變化之最單純工具。

The effects of degradation of ranitidine hydrochloride exposed to UVB radiation (l = 310 nm) and oxygen in a weathering chamber were studied by Fourier Transform Infrared spectroscopy (FTIR) and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR). ATR-FTIR profile indicated that the degradation was spatially heterogeneous. Significant amounts of photoproducts were detected only in a directly irradiated layer. Major damage/change was reflected in the appearance of broad, extended group of signals near the wavenumber 3600-3200 cm-1 or/and 3500-3400 cm-1. We examined whether FTIR-ATR technique is a great tool to observe the simplest and the first changes on the surface of a substance in powder.