以離子選擇電極檢測普潘奈藥物劑型中不同有序介質之影響   全文下載

Effect of Different Organized Media on Ion-Selective Electrode (ISE) Determination of Propranolol in Pharmaceutical Dosage Forms

本研究係為檢測普潘奈（propranolol）在不同有序介質（organized media）， 如β- 環糊精（β-cyclodextrin） 及陰離子型（sodium dodecyl sulphate）、陽離子型（cetrimide）或非離子型（tween-20 及tween-80）的微胞介面活性物質（micelle surfactants），以tetraphenyl borate（PRO-TPB）離子交換之聚乙稀膜選擇電極檢測電位效應。結果發現普潘奈濃度大於1 × 10-5 ~10-2 M 時，不會被非離子介面活性劑影響，而陽離子界面活性劑會明顯減少能斯特（Nernstian）斜率，陰離子界面活性劑則相反。電極基本分析參數如測量範圍、斜率、偵測極限、反應時間及選擇系數都與有序介質是否存在某些無機陽離子、糖、氨基酸及β- 阻斷劑有關。

This study examined the effect of different organized media such as β-cyclodextrin and micelle surfactants, either anionic (sodium dodecyl sulphate), cationic (cetrimide) or non-ionic (tween-20 and tween-80), on the potentiometric properties of propranolol polyvinyl chloride selective electrode based on tetraphenyl borate (PRO-TPB) ion-exchanger as an electroactive material. It was found that the Nernstian slope for propranolol over the concentration range of 1 × 10-5 to 10-2 M was unaffected by non ionic surfactant, whereas cationic surfactant significantly decreased the Nernstian slope. However, anionic surfactant significantly increased the Nernstian slope. The electrode basic analytical parameters such as measurement range, slope characteristics, detection limit, response time, and selectivity coefficients in relation to some inorganic cations, sugars, amino acids and some β-blockers were investigated in presence or absence of organized media. Electrode was used for the potentiometric determination of propranolol in pharmaceutical preparations with and without organised compounds. The results were consistent with those obtained using a reference method.