牛磺酸對於老鼠攝食氧化膽固醇所產生的毒性作用影響   全文下載

Effect of Taurine on Toxicity of Oxidized Cholesterol in Rats

氧化膽固醇在食品中如蛋製品、牛油、豬油、乳製品、肉製品、滷味食品及水產品等及其對人體之健康影響已受到重視，本研究針對攝食食品中含有氧化膽固醇所產生的毒性影響及添加牛磺酸後對雄性Wistar 老鼠之影響，以48 隻老鼠分成8 大組，餵食添加牛磺酸（5%）和氧化的膽固醇（3%）及沒有添加牛磺酸和氧化的膽固醇的老鼠分別飼養兩個月，評估牛磺酸添加在食物中及在攝食前或攝食後之影響，並且分析老鼠血液中之生化指標等，實驗發現在餵食牛磺酸可以降低老鼠因攝食氧化膽固醇所減少的體重（P < 0.05），增加肝臟的 glutathione（GSH）（P<0.05），減少攝食氧化膽固醇所增加肝臟中的thiobarbituric acid-reactive substances（tBARS）和降低老鼠血液中的aspartate transaminase（ASt）、alanine transaminase（ALt）、alkaline phosphatase（ALP）和肝體比和腎體比（P < 0.05），由此顯示食物中添加牛磺酸在老鼠的飲食中可預防和降低氧化膽固醇所產生的毒性作用比較明顯，並扮演重要的角色。

This research was aimed to study the effect of dietary taurine on the toxicity of oxidized cholesterol in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 3% oxidized cholesterol for 8 weeks. To evaluate effects of taurine at the same time, before diets and after diets in the food, after feeding diet with 3% oxidized cholesterol and 5% taurine at the same time, taurine could improve the decrease of body weight and the glutathione (GSH) level in the liver, and the increase of relative ratio of liver or kidney weight to body weight and thiobarbituric acid-reactive substances (TBARS) level in the liver of rats caused by oxidized cholesterol (P < 0.05). It also could inhibit the activities of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) in the plasma of rats caused by oxidized cholesterol (P < 0.05). It was also found that taurine possessed a good recovering effect and a short-term preventing effect the toxicity of oxidized cholesterol in rats. Judging from these data, on taurine may play an important role in diminishing the toxic effect of oxidized cholesterol in rats.