健康食品中摻加減肥藥諾美婷類緣物成分之純化與鑑定   全文下載

Isolation and Identification of a Sibutramine Analogue in a Healthy Food for Weight Loss

一種暗示具減肥效果之食品，檢出非法摻加諾美婷類緣物之減肥西藥成分（sibutramine analogue），其結構經鑑定為N-1-[1-（4-chlorophenyl） cyclobutyl]-3-methylbutyl-N-methylamine。該食品檢體先以純水溶解，鹼化去鹽基，以二氯甲烷進行液-液分配萃取純化，再由一維與二維核磁共振儀（1H-NMR, 13C-NMR, COSY, DEPT, HMQC, HMBC）、紅外線吸收光譜儀（IR）及快速原子撞擊質譜儀（FAB）等儀器鑑定並定出其結構，確認為諾美婷類緣物。此係首次發現之非法添加諾美婷類緣物成分，為保障民眾健康，已將此成分列為非法摻加西藥例行檢查項目之一。"

A sibutramine analogue was detected and added illegally in known as the healthy food that can reduce weight. The structure was determined as N-1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutyl-N-methylamine with the molecular formula C16H24NCl and molecular weight 265 Da. The sample was desalted and extracted with water, further purified by a liquid-liquid partition method. The structure was identified with a series of 1-D and 2-D NMR techniques, IR and FAB mass. Comparing with the structure of sibutramine, a tertiary amine was substituted as a secondary amine. This is one of the active metabolite of sibutramine. Basic on the law, foods with any illegal additive such as synthetic chemical compound shall not be sold, manufactured, imported, processed, used, prepared, stored or transported. Therefore, this sibutramine analogue has been included in the inspection list of illegal adulterants in Taiwan.