食用疣織紋螺及粗果織紋螺所引起之河魨毒素中毒案件   全文下載

Occurrence of Tetrodotoxin Poisoning in Nassarius Papillosus Alectrion and Nassarius Gruneri Niotha

西元2002年5月15日，台灣高雄地區一對夫妻食用不知名螺類兩小時後產生嘔吐、下痢及其他神經中毒現象之食物中毒徵狀，此不知名螺類經鑑定為先織紋螺及粗果織紋螺。利用河魨毒素之小鼠試驗法得知先織紋螺及粗果織紋螺每公元克分別含有320及386小鼠單位（mouse unit；MU）之河魨毒素。並將純化之河魨毒素利用高效液相層析分析顯示造成中毒之毒素為河魨毒素及其衍生物去氫河魨毒素。

On May 15, 2002, a food poisoning case caused by consumption of unknown gastropods was reported. Symptoms included vomiting, diarrhea and other neurological symptoms developed 2 hr after ingestion of gastropods. The unknown species of gastropod were later identified to be Nassarius Papillosus Alectrion and Nassarius Gruneri Niotha. Using a tetrodotoxin bioassay, the two samples showed toxicity of 320 and 386 mouse units per gram (MU/g) in Nassarius Papillosus and Nassarius Gruneri. The result of high performance liquid chromatography (HPLC) on the purified toxin indicated that the causative toxic agents were tetrodotoxin and its derivative anhydrotetrodotoxin. 西元2002年5月15日，台灣高雄地區一對夫妻食用不知名螺類兩小時後產生嘔吐、下痢及其他神經中毒現象之食物中毒徵狀，此不知名螺類經鑑定為先織紋螺及粗果織紋螺。利用河魨毒素之小鼠試驗法得知先織紋螺及粗果織紋螺每公元克分別含有320及386小鼠單位（mouse unit；MU）之河魨毒素。並將純化之河魨毒素利用高效液相層析分析顯示造成中毒之毒素為河魨毒素及其衍生物去氫河魨毒素。