美國藥物食品管理局，國家毒理研究中心對光毒性與光致癌性效應之研究   全文下載

Phototoxicology and Photocarcinogenesis at the U.S. Food and Drug Administration’s National Center for Toxicological Research

紫外線輻射會引起人類及實驗動物皮膚癌，另已有文獻報導紫外線輻射會與許多藥物產生交互作用，然而化粧品成分及環境污染物中，哪些成分經紫外線照射會致癌之報導卻不多。因此，美國藥物食品管理局國家毒理研究中心開發可量化化合物經曝露於紫外線輻射之致癌性，該中心進行試驗之化合物係屬國家毒理研究計畫所指定與批准之化合物。本文將敘述這些化合物，及所採用之實驗動物、紫外線輻射源、劑量及試驗範例等。該試驗機構對大眾會曝露之化合物，透過量化其致光致癌性，以確保公眾健康。

Ultraviolet radiation (UVR) causes skin cancer in humans and can induce skin cancer in test animals. The interaction of UVR with many drugs has been reported, however, there is a paucity of data concerning the carcinogenesis of cosmetic ingredients and environmental contaminants in combination with UVR. A research center has been developed at the U.S. Food and Drug Administration's National Center for Toxicological Research to quantify the potential carcinogenicity of combined exposure to chemicals and UVR. The chemicals tested in this facility are nominated to, and approved by, the National Toxicology Program. In this paper we describe the nomination of chemicals, test animals, source of UVR, dosimetry, and test paradigm that are used. This unique test facility is being used to protect public health through quantifying the photocarcinogenicity of chemicals to which the public is exposed. 紫外線輻射會引起人類及實驗動物皮膚癌，另已有文獻報導紫外線輻射會與許多藥物產生交互作用，然而化粧品成分及環境污染物中，哪些成分經紫外線照射會致癌之報導卻不多。因此，美國藥物食品管理局國家毒理研究中心開發可量化化合物經曝露於紫外線輻射之致癌性，該中心進行試驗之化合物係屬國家毒理研究計畫所指定與批准之化合物。本文將敘述這些化合物，及所採用之實驗動物、紫外線輻射源、劑量及試驗範例等。該試驗機構對大眾會曝露之化合物，透過量化其致光致癌性，以確保公眾健康。