人體與家畜等動物來源鼠傷寒沙門氏菌抗生素圖譜之比較   全文下載

A Comparison of Antibiograms for the Salmonella typhimurium Isolates from Humans and Domestic or Other Animals in Taiwan

本研究蒐集台灣地區人體分離鼠傷寒沙門氏菌（S. typhimurium）菌株45 株，台灣牛豬等家畜分離菌株87 株，蒐集時間自1990 至1996 年間，以十種抗生素tetracycline （Te）、sulfisoxazole （G）、ampicillin （Am）、chloramphenicol （C）、streptomycin （S）、trimethoprim-sulfamethoxazole （Sxt）、kanamycin （K）、gentamicin （Gm）、norfloxacin （Nor）、cefoperazone （Cfp），調查不同來源菌株對各種抗生素之耐受性，並比較人體與家畜分離菌株對抗生素之抗性差異。結果發現，人體與家畜分離株之抗生素圖譜十分類似，以TeGAmSC 為主要抗藥類型。台灣地區人體與動物分離菌株對第一線抗生素如tetracycline、sulfisoxazole 、ampicillin 、streptomycin 、chloramphenicol 具高抗藥性，對fluoroquinolone 類抗生素如norfloxacin 、第三代頭芽胞菌素cefoperazone 與gentamicin則為感受性， 100 ~ 93%之本地區菌株受其抑制。台灣鼠傷寒沙門氏菌菌株，多重抗藥性比例高，動物來源佔58.6%，人體來源菌株亦有68.9%為多重抗藥性。本研究結果可瞭解本地區分離之人體與家畜等動物來源鼠傷寒沙門氏菌抗生素圖譜相近，此可能由於台灣地區幅員小，而鼠傷寒沙門氏菌為人畜共通病原菌所致；此外本地區分離之菌株抗藥性高，可能與台灣地區抗生素之施用未嚴格管制有關。 The antibiograms of 45 human isolates and 87 animal isolates of Salmonella typhimurium collected from 1990 to 1996 in Taiwan were investigated. The antibiotics used were tetracycline (Te), sulfisoxazole (G), ampicillin (Am), chloramphenicol (C), streptomycin (S), trimethoprim- sulfamethoxazole (Sxt), kanamycin (K), gentamicin (Gm), norfloxacin (Nor) and cefoperazone (Cfp). Resistance to antibiotics for these Salmonella isolates was studied, and the results obtained for human and animal isolates were compared. It was found that the antibiograms for human and animal isolates are quite similar. The major resistant type for these Salmonella strains is TeGAmSC. Both the human and animal isolates are highly resistant to first-line antibiotics, such as tetracycline, sulfisoxazole, ampicillin, streptomycin of chloramphenicol; but are sensitive to fluoroquinolone antibiotics, such as norfloxacin and the third generation antibiotic of cephalosporin, such as cefoperazone and gentamicin. Between 93 % and 100 % of the local strains is inhibited by these antibiotics. Also, a significant fraction of these S. typhimurium isolates are multidrug resistant strains. For example, 58.6% of the animal isolates and 68.9% of the human isolates are multidrug-resistant. In conclusion, the antibiograms for human and animal isolates of S. typhimurium are similar. These results may be owing to the fact that Taiwan is geographically a small island and S. typhimurium strains are the common infective strains for human and domestic animals. Also, a high fraction of these strains was found to be drug resistant, which may be attributed to the fact that antibiotics are not strictly restricted for use in Taiwan."

The antibiograms of 45 human isolates and 87 animal isolates of Salmonella typhimurium collected from 1990 to 1996 in Taiwan were investigated. The antibiotics used were tetracycline (Te), sulfisoxazole (G), ampicillin (Am), chloramphenicol (C), streptomycin (S), trimethoprim- sulfamethoxazole (Sxt), kanamycin (K), gentamicin (Gm), norfloxacin (Nor) and cefoperazone (Cfp). Resistance to antibiotics for these Salmonella isolates was studied, and the results obtained for human and animal isolates were compared. It was found that the antibiograms for human and animal isolates are quite similar. The major resistant type for these Salmonella strains is TeGAmSC. Both the human and animal isolates are highly resistant to first-line antibiotics, such as tetracycline, sulfisoxazole, ampicillin, streptomycin of chloramphenicol; but are sensitive to fluoroquinolone antibiotics, such as norfloxacin and the third generation antibiotic of cephalosporin, such as cefoperazone and gentamicin. Between 93 % and 100 % of the local strains is inhibited by these antibiotics. Also, a significant fraction of these S. typhimurium isolates are multidrug resistant strains. For example, 58.6% of the animal isolates and 68.9% of the human isolates are multidrug-resistant. In conclusion, the antibiograms for human and animal isolates of S. typhimurium are similar. These results may be owing to the fact that Taiwan is geographically a small island and S. typhimurium strains are the common infective strains for human and domestic animals. Also, a high fraction of these strains was found to be drug resistant, which may be attributed to the fact that antibiotics are not strictly restricted for use in Taiwan.