市售中藥補養劑四種重金屬含量之調查   全文下載

Investigation on Four Heavy Metal Constituents of Commercial Restorative Chinese Medicines

針對市售十家科學中藥廠的防風通聖散、金索固精丸、天王補心丹、補中益氣湯、四物湯等五種補養劑之濃縮散劑、濃縮顆粒劑、錠劑、丸劑，以硝酸－－過氯酸為消化液，經微波消化後，藉石墨爐式或火燄原子化式原子吸收光譜儀進行鎘、鉻、錳、鉛等四種重金屬含量檢測。檢測結果得知，錳含量偏高（27.9 ± 19.8 ppm），其餘含量分別為鉻2.86 ± 2.04 ppm、鉛0.247 ± 0.578 ppm、鎘0.157 ± 0.167 ppm。不同廠牌間、不同處方間、同一處方之各劑型間、甚至同一家藥廠不同批號，由於藥材種類、來源與添加劑之不同，重金屬含量有差異存在。依處方別計算四種重金屬總含量，金索固精丸（53.6 ± 74.7 ppm）明顯高於其他處方。為保障用藥人之安全，並提昇科學中藥之品質，建議針對各種重金屬毒性分別制定限量標準。

This study undertook the analysis of Cd, Cr, Mn, and Pb constituents in the various forms of five restorative preparations from ten GMP Chinese medicine laboratories. Collected samples of the commercial drugs were digested with HNOJ-HCI04 in the presence of microwaving, followed by atomic absorption spectrophotometric analysis. The results showed higher levels in the Mn content (27.9±19.8 ppm) than Cr (2.86±2.04 ppm), Pb (0.247±0.578 ppm), and Cd (0.157±0.167 ppm), based on the dry weight of the samples. The variation of heavy metal contents between laboratories, prescriptions, prescribed doses, and lot numbers may be attributed to the differences in the origin of raw materials as well as the additives used in the processing procedure. Comparison between prescriptions exhibited higher heavy metal contents (53.6±24.7 ppm, the sum of Cd, Cr, Mn and Pb) in Kim-So-Ku-Gien-Wan. For purposes of safety and quality in Chinese drugs, it is necessary to confine individual heavy metal content on the basis of potential toxicity.