睡眠呼吸中止症口腔治療器之文獻回顧

Review of Oral Appliance on OSA (OBSTRUCTIVE SLEEP APNEA)

阻塞型睡眠呼吸中止症是最常見的睡眠呼吸障礙，其典型症狀為響亮且不規律的鼾聲與睡眠中多次的清醒。阻塞型睡眠呼吸中止症通常與心血管與代謝疾病息息相關。許多研究證實治療阻塞型睡眠呼吸中止症對患者有明顯益處。而持續性呼吸道正壓治療為阻塞型睡眠呼吸中止症標準治療方式，但仍有許多患者無法適應。而口腔治療器為治療輕度到中度阻塞型睡眠呼吸中止症的替代療法。本篇以文獻回顧方式討論口腔治療器治療睡眠呼吸中止症的成效、機轉、臨床治療建議以及未來展望。

Obstructive sleep apnea (OSA) is the most common category of sleep-disordered breathing. The common signs of OSA include loud and irregular snoring and disturbed sleep due to the multiple awakenings. OSA is frequently associated with cardiovascular and metabolic disorders. Many studies have confirmed that there are clear benefits for patients who treated OSA. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA, but there are many patients with OSA who are intolerant of CPAP therapy. Oral appliance treatment is alternative therapy for mild to moderate OSA. This article makes some literature reviews and discusses effect, mechanisms, clinical guideline and further studies of oral appliance therapy for OSA.