| 英文摘要 |
In a sensible sensitive address to the department of gastroenterology andhepatology, Chang Gung Memorial Hospital emphasized aristolochic acids mightbe the cause of hepatocellular carcinoma (HCC) in Taiwan, based on “Aristolochicacids and their derivatives are widely implicated in liver cancers in Taiwan andthroughout Asia”. Rise of the bias originates from the exploratory retrospectiveresearch the study submitted. The aim of this article is to appraise the publishedpaper and instruct relatively fair research findings.We found this type of study design is given the prevalence of aristolochicacid signature in Taiwan HCC, rather testing for a causal inference. It would be more appropriate to set the press topic as “approximately 80% of HCC samplescollected from two northern medical centers might be in contact with substancesthat contain aristolochic acid, and further researches are suggested to clarity thecausal relationship between HCC and aristolochic acid”. Propagating scientificresult objectively is recommended to medical personnel. |
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