| 英文摘要 |
Background: Glucosamine is a commonly used treatment for patients withdegenerative arthritis that helps prevent cartilage wear and damage and slowsdown the pain symptoms of degenerative knee arthritis. Previous studies have alsofound that a high proportion of patients with degenerative arthritis will receiveChinese medicine treatment, but there is no detailed statistical study of Westernmedicine. To realize the prescription pattern of degenerative knee arthritis, thisstudy would explore the combined use of Du-Huo-Ji-Sheng-Tang and glucosamine(Glucosamine) and calculate the factors that may affect use patterns. We analyzedthe impact of combined use on total knee replacement and reducing the need fornon-steroidal anti-inflammatory drugs.Methods: In this study, the retrospective method was used to collect thepatients who had been diagnosed with degenerative knee arthritis and treatedwith Glucosamine from 1997 to 2003, and then the TCM medical information,Analysis of patients taking traditional Chinese medicine compound solitary Du-Huo-Ji-Sheng-Tang. The study will also be age, gender, urbanization degree ofliving areas, patients health insurance costs as a classification of variables, andincluded chronic diseases such as diabetes, hypertension, chronic kidney disease,heart disease, rheumatoid arthritis. The use of logical regression analysis andthe use of solitary Du-Huo-Ji-Sheng-Tang with or without the above variables are different. We used Kaplan-Meier curves to compare the survival curves ofpatients undergoing total knee arthroplasty and using the log-rank test to testthe significance of the two measures. The risk ratio is calculated using the Coxproportional hazard model method and corrects variables such as age, gender,place of residence, insured amounts, and comorbid conditions. We counted thepatient's total amount of non-steroidal anti-inflammatory painkiller and convertedto a defined daily dose. We used an independent t-test to assess differences in nonsteroidalanti-inflammatory analgesics between the two groups.Results: Of the 36,016 patients with degenerative knee arthritis, 26,257 patientswere excluded from the analysis of patients who were not initially diagnosedduring the study, with incomplete data, and who did not take Glucosamine. Ofthese, 4738 (18.2%) were treated with independent live parasites, and 21,474(81.8%) were absent. Analysis of factors that may affect the use of Chineseand Western medicine, it is found that with the older, the lower the degree ofurbanization in the living area, and the higher the cost of health insurance, thepatient with glucosamine and the only chance of Du-Huo-Ji-Sheng-Tang. Atthe same time if the patient tends to use coronary artery disease is also higher,relatively high blood pressure in patients with lower and possible. Patients whoreceived combine threapy lower rates of total knee arthroplasty and a p-value ofthe log-rank test of less than 0.05, achieving a statistically significant difference.The adjusted odds ratio and 95% confidence interval were 0.84 (0.71-0.94). Theaverage number of patients who used combined live alone soup was lower thanthat of patients on pure glucosamine alone, with an average of 23.57 defined dailydoses.Conclusions: The combination of Chinese and Western medicine is a commonpractice for Taiwanese people. This study found that age, economic situationand living area, and whether chronic diseases are likely to affect the tendency ofpatients with glucosamine and bovine parasite soup. Combined use can reduce thetotal amount of non-steroidal anti-inflammatory drugs, and total knee replacementsurgery needs. |
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