高劑量靜脈注射維生素C對急性皰疹痛的療效

Effectiveness of High-dose Intravenous Vitamin C on Acute Herpetic Pain

靜脈注射高劑量維生素C可望成為急性皰疹痛的有效療法，但目前尚未確立其最低有效劑量及目標血清濃度。曾有研究指出靜脈注射總劑量60至75克的維生素C可有效緩解急性皰疹痛，但15克則無效。在此報告，急性皰疹痛的痫例，以傳統方式治療無效，但靜脈注射高劑量維生素C（總劑量各為40及30克）可有效減輕疼痛；維生素C的最終血清濃度各為23.1及20.3 Hg / ml。由以上發現可見維生素C對於急性皰疹痛的療效與劑量有關，而且維生素C的血清濃度可能需大於20μg/ ml才足以緩解急性皰疹痛。

Intravenous high-dose vitamin C is a potentially useful therapy for acute herpetic pain,but its minimum effective dose and target serum concentration have not been established.It was reported that intravenous vitamin C in a total dose of 60-75 g was effective in mitigating acute herpetic pain,while that of 15 g was not.We report two cases whose acute herpetic pain was resistant to traditional treatment but effectively relieved by intravenous high-dose vitamin C(total doses 40 and 30 g,respectively); final serum levels of vitamin C were 23.1 and 20.3μg/ ml,respectively.These findings support the notion that the effect of vitamin C on acute herpetic pain is dose-dependent,and a serum vitamin C level greater than 20μg/ ml may be needed to relieve acute herpetic pain.