| 中文摘要 |
目的：探討新診斷失憶症與失智症之關聯性。方法：我們使用全民健保資料庫之百萬歸 人檔，辨識出 5,396 位年齡 20 歲以上且無過去失憶症病史之研究組病人。其中，1,349 位為 新診斷失憶症病人，依據年齡、性別、人口學變項、查爾森共病指數及指標日期等變項，以 傾向分數進行配對，依 1：3 之比例，取得 4,062 位為對照組。以范—葛瑞二氏競爭風險存 活分析比較 10 年追蹤期間兩組發生失智症之風險。結果：個案組中，1,349 位病人有 440 位 （32.62%） 出現失智症而控制組中 4,047 位病人有 155 位 （3.83%） 出現失智症。競爭風險存活分 析呈現研究組個案有顯著的較高風險出現失智症 （hazard ratio = 17.536, 95% confi dence interval = 14.487 - 21.226, p < 0.001）。經過性別、年齡、月收入、都市化程度、居住區域及共伴疾 病之校正後，其出現顯著的失智症之風險比為 17.222 （95% CI = 13.611 - 20.078），而且也有顯 著的高風險性 （p < 0.001）。結論：新診斷失憶症之病人出現失智症之風險為 16 倍。 |
| 英文摘要 |
Objective: We intended to study the association between the newly diagnosed amnestic disorders and dementia. Methods: We used a subset of Taiwan's National Health Research Institute Database, containing one million randomly sampled subjects to identify 5,396 patients aged ≥ 20 years without a history of amnestic disorders. We enrolled 1,349 patients with newly diagnosed amnestic disorders, and propensity score-matched 4,047 controls for age, gender, demographic covariates, Charlson comorbidity index, and index-date at a ratio of 1: 3. After adjusting for confounding factors, we used Fine and Gray's competing risk survival analysis to compare the risk of developing dementia of the two groups during a 10-year follow-up. Results: Of the study subjects, 440 in 1,349 (32.62%) developed dementia compared to 155 in 4,047 (3.83%) of the controls. The study subjects were signifi cantly to develop dementia (hazard ratio = 17.536, 95% confi dence interval = 14.487 - 21.226, p < 0.001). After adjusting for confounding factors, the HR for dementia was 16.531 (95% CI =13.611 - 20.078), which also signifi cantly different (p < 0.001). Amnestic disorders were signifi cantly associated with the increased risk of Alzheimer, vascular, senile and pre-senile, and alcoholic types of dementia (all p < 0.001) Conclusion: The patients with newly diagnosed amnestic disorder had a 16-fold increased risk of developing dementia. |
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