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篇名
新診斷失憶症與失智症:一項全國性之世代研究
並列篇名
The Newly Diagnosed Amnestic Disorders and Dementia: A Nationwide, Cohort Study in Taiwan
作者 高廉程簡戊鑑鍾其祥葉慧雯周雨青黃三原葉啟斌張勳安高譽誠江瑋珊葉奕緯曾念生
中文摘要
目的:探討新診斷失憶症與失智症之關聯性。方法:我們使用全民健保資料庫之百萬歸 人檔,辨識出 5,396 位年齡 20 歲以上且無過去失憶症病史之研究組病人。其中,1,349 位為 新診斷失憶症病人,依據年齡、性別、人口學變項、查爾森共病指數及指標日期等變項,以 傾向分數進行配對,依 1:3 之比例,取得 4,062 位為對照組。以范—葛瑞二氏競爭風險存 活分析比較 10 年追蹤期間兩組發生失智症之風險。結果:個案組中,1,349 位病人有 440 位 (32.62%) 出現失智症而控制組中 4,047 位病人有 155 位 (3.83%) 出現失智症。競爭風險存活分 析呈現研究組個案有顯著的較高風險出現失智症 (hazard ratio = 17.536, 95% confi dence interval = 14.487 - 21.226, p < 0.001)。經過性別、年齡、月收入、都市化程度、居住區域及共伴疾 病之校正後,其出現顯著的失智症之風險比為 17.222 (95% CI = 13.611 - 20.078),而且也有顯 著的高風險性 (p < 0.001)。結論:新診斷失憶症之病人出現失智症之風險為 16 倍。
英文摘要
Objective: We intended to study the association between the newly diagnosed amnestic disorders and dementia. Methods: We used a subset of Taiwan's National Health Research Institute Database, containing one million randomly sampled subjects to identify 5,396 patients aged ≥ 20 years without a history of amnestic disorders. We enrolled 1,349 patients with newly diagnosed amnestic disorders, and propensity score-matched 4,047 controls for age, gender, demographic covariates, Charlson comorbidity index, and index-date at a ratio of 1: 3. After adjusting for confounding factors, we used Fine and Gray's competing risk survival analysis to compare the risk of developing dementia of the two groups during a 10-year follow-up. Results: Of the study subjects, 440 in 1,349 (32.62%) developed dementia compared to 155 in 4,047 (3.83%) of the controls. The study subjects were signifi cantly to develop dementia (hazard ratio = 17.536, 95% confi dence interval = 14.487 - 21.226, p < 0.001). After adjusting for confounding factors, the HR for dementia was 16.531 (95% CI =13.611 - 20.078), which also signifi cantly different (p < 0.001). Amnestic disorders were signifi cantly associated with the increased risk of Alzheimer, vascular, senile and pre-senile, and alcoholic types of dementia (all p < 0.001) Conclusion: The patients with newly diagnosed amnestic disorder had a 16-fold increased risk of developing dementia.
起訖頁 18-28
關鍵詞 失憶症失智症全民健保資料庫世代研究amnestic disordersdementiaNational Health Research Institute Databasecohort study
刊名 台灣精神醫學雜誌  
期數 201803 (32:1期)
出版單位 台灣精神醫學會
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