高纖維飲食攝取可改善精神病患者因服用抗精神病藥物所造成之體重增加

High Dietary Fiber Intake Improves Psychiatric Patients' Weight Gain due to Taking Antipsychotics

因為精神病患病情所需，在治療的同時活動空間會有所侷限，除了藥物本身副作用 以外再加上運動量的不足，以致肥胖、糖尿病、高血壓等代謝方面疾病便隨著療程延長 罹患率隨之增高。本研究希望藉由低熱量、高纖維飲食之攝取，減輕或延緩服用第一型 抗精神分裂症藥物(First generation antipsychotic drug; FGA)、第二型抗精神分裂症藥 物(Second-generation antipsychotic drug; SGA)病患體重增加並降低代謝症候群發生 率。實驗結果可看出對照組的體位測量結果呈現上升趨勢，實驗組的體位測量結果呈現 下降趨勢，且對照組與實驗組攝取熱量及纖維攝取量有顯著性差異(p<0.05) ，體重、腰 ，體重、腰臀比與膳食纖維之攝取呈顯著相關性 臀比與膳食纖維之攝取呈顯著相關性 (p<0.05) ，以及血液中HDL 和服用藥物種類有顯 和服用藥物種類有顯著相關性 (p<0.05) 。本研究中仔細檢查個體飲食和藥物攝入量後，我們得出高抗纖維低熱量 飲食的受試者在抗精神病藥物治療時確實保持或減少體重結論，由此可印證適當 之飲食熱量控制及膳纖維補充可適當的調SGA引致代謝相關性副作用。

Because of the special needs of a psychotic patient during the treatment phase where space is limited, the side effects of antipsychotic drugs plus the lack of exercise has increased the patient's chance of obesity, diabetes, high blood pressure, and other metabolism related problems. The present research seeks to evaluate the effectiveness of low-calorie, high fiber food in helping patients on first generation antipsychotic drug (FGA) and second generation antipsychotic drug (SGA) to reduce their body weight increase or metabolic syndrome. The individual results did show the difference in the calories and fiber intake between the comparison group and experimental group is statically significant (p<0.05), and the weight and waist to hip ratio show correlation with the fiber intake (p<0.05), as well as the HDL of blood did show a statically significant difference correlated with the type of antipsychotic (p<0.05). Upon a closer inspection of the individual diet and medicine intake in the present research, we conclude that the subjects a high fiber low calorie diet did maintain or decrease their body weight when under antipsychotic medication. From this we deduce that the proper intake of high fiber/low calorie foods can mediate the metabolic illnesses as a side effect of SGA.