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篇名
Neuraxial magnesium sulfate improves postoperative analgesia in Cesarean section delivery women: A meta-analysis of randomized controlled trials
作者 Shih-Ching Wang (Shih-Ching Wang)Po-Ting Pan (Po-Ting Pan)Hsiao-Yean Chiu (Hsiao-Yean Chiu)Chun-Jen Huan (Chun-Jen Huan)
中文摘要
Background: We conducted this meta-analysis to elucidate whether additional neuraxial magnesium sulfate (MgSO4) can improve postoperative analgesia in women undergoing Cesarean section (CS) delivery. Method: We searched Pubmed, Embase and ClinicalTrial.gov. We included only randomized controlled trials that have compared the quality of postoperative analgesia with and without additional neuraxial MgSO4 in women undergoing CS delivery with neuraxial anesthesia regimens. The primary outcomes included analgesic duration of neuraxial anesthesia, postoperative pain scores and postoperative consumption of analgesics. The secondary outcomes included patients' satisfaction and adverse effects related to postoperative analgesia. Results: Nine relevant studies comprising a total of 827 women undergoing CS delivery were included. Analyses revealed that CS women receiving additional neuraxial MgSO4 (the MgSO4 group) had longer duration of neuraxial anesthesia (effect size [ES] = 1.920, 95% confidence interval [CI] = 0.999 to 2.842, P < 0.001), longer duration of sensory block (ES = 1.020, 95% CI = 0.463 to 1.577, P < 0.001), lower postoperative pain scores at rest (ES = 1.206, 95% CI = 2.084 to 0.329, P = 0.007), pain scores with motion (ES = 1.435, 95% CI = 2.631 to 0.240, P = 0.019) and consumption of analgesics (ES = 1.620, 95% CI = 2.434 to 0.806, P < 0.001) than CS women without receiving additional neuraxial MgSO4 (the control group). Of note, the MgSO4 group tended to have higher rate on rating satisfaction as “excellent” than the control group did (odds ratio = 3.748, 95% CI = 2.218 to 6.332, P < 0.001). However, the incidences of adverse effects (i.e., nausea and vomiting, pruritus and hypotension) were not significantly different between these two groups. Conclusion: Neuraxial MgSO4 improves postoperative analgesia in CS women
起訖頁 56-67
關鍵詞 Magnesium sulfateCesarean sectionPostoperative analgesia
刊名 麻醉學雜誌  
期數 201709 (55:3期)
出版單位 台灣麻醉醫學會
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該期刊-下一篇 Pre-emptive ketorolac for prevention of intraoperative shoulder pain in patients undergoing cesarean section: A double blind randomized clinical trial
 

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