蛋白質體於類風濕性關節炎的應用

Proteomics in rheumatoid arthritis

生物體的功能最主要由基因的產物蛋白質所表現，蛋白質體乃是探討及評估蛋白質及其交互作用的學問。藉由二維電泳及質譜分析，我們可以了解蛋白質在生物訊息扮演的角色。蛋白質體在類風濕關節炎的應用，已漸被重視，因此我們收集相關文獻，並探討其未來的潛在發展效益。

Proteomics have been developed for 15 years. Traditionally, biochemical methods have been used to study proteins. In the modern era, the term proteomics covers the functional analysis of gene products, including identification of proteins and their interactions. Proteomics is now a science dealing with various proteins based on a combination of several methods: 2-dimensional electrophoresis, mass-spectrometric analysis of molecular masses, and sequencing of electrophoretically divided proteinaceous biological material with subsequent analysis of the results obtained by use of bio-informatic methods. Proteomics also can also be used for the monitoring of reversible posttranslational modification of proteins by specific enzymes, such as phosphorylation, glycosylation, acylation, phrenylation, citrillunation, or sulfurization. Recently, many reports of proteomic use in rheumatoid arthritis have been published. We will review these reports and summarize current proteomic advances in these fields.