發生於紅斑性狼瘡的再生不良性貧血症：一致死性的病例報告

Fatal Aplastic Anemia in Systemic Lupus Erythematosus: A Case Report

全身性紅斑性狼瘡的病患常出現各式輕重不一的血球減少症，主要是導因於周邊血液中自體免疫抗體的破壞。骨髓和造血幹細胞很少被侵犯。雖然某些再生不良性貧血是由自體免疫機轉所導致，但很少發生在紅斑性狼瘡的病人身上，這種罕見的併發症可能是因病患血液中存在幹細胞抑制因子。當病患發生異常的全血球低下時，應盡早做骨髓檢查。雖然我們的個案發生致命性的血球低下，但根據文獻中的病例報告，施予各種免疫抑制療法通常可以獲致很好的治療預後。

Cytopenia due to autoantibody destruction in peripheral blood is frequently encountered in systemic lupus erythematosus (SLE). The bone marrow and stem cells are rarely involved. Full-blown aplastic anemia may be caused by autoimmune mechanism but rarely occurs in SLE patients. We here report such a case who developed severe pancytopenia with a fatal outcome.