| 英文摘要 |
Malignant hyperthermia (MH), the nightmare for all anesthesiologists, is a life-threatening genetic sensitivity of skeletal muscles to volatile anesthetics and depolarizing neuromuscular blocking drugs. In Europe and North America, MH was the commonest cause of death directly attributable to general anesthesia in 1970. Since the introduction of skeletal muscle relaxant, dantrolene, case-fatality rate in MH has fallen from 70% in the 1970s to 5% today. With proper monitoring and timely administration of dantrolene, MH is no longer regarded as a formidable catastrophe but rather accepted as a preventable and treatable disease. Despite dramatic improvement throughout the past decades, MH has raised profound public concern in Taiwan and emerged as an administrative debate when two consecutive patients died from apparent lack of dantrolene in 2003. |
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