Patent Blue造成長時間動脈血氧飽和度監測儀讀數混亂

Prolonged Interference of Patent Blue on Pulse Oximetry Readings

背景；我們試著評估PatentBlue(PB)造成動脈血氧飽和度監測儀讀數混亂程度，及試著找出可能影響因子。方法：我們找到十位欲接受動脈內管化學治療的女性患者，所有病人均在心電圖、動脈血氧飽和度監測儀及直接動脈血壓的監測下進行標準麻醉和麻醉後監測。我們在下刀前及注射PB後分別取得並記錄動脈血氧飽和度、血色素濃度及直接由動脈血測得的動脈血氧和動脈血氧飽和度來作比較。另外，我們也由CO-Oximetry來分析真實的動脈血氧飽和度，並比較兩者時期的差別，及試著找出可能影響因子。結果：我們發現由動脈血氧飽和度監測儀所測得動脈血氧飽和度在注射PB後有明顯統計上的下降，而在術後兩小時動脈血氧飽和度監測儀所測得動脈血氧飽和度的下降程度，和所注射的PB劑量有關(rs =-0.846，P< 0.05)，而和其他血色素濃度或PB劑量／血色素濃度比值等無統計上的相關。結論：可造成長時間動脈血氧飽和度監測儀讀數錯誤地下降，而其下降程度可能和所注射的PB劑量有關。

Background: We evaluated the effect of intra-arterial injection of Patent Blue (PB) on pulse oximetry. Methods: Ten consecutive female patients who underwent intra-arterial insertion of catheter for chemotherapy were enrolled in this study. All patients received general anesthesia and ECG, pulse oximetry, and direct arterial bood pressure were monitored throughout the perioperative period. Baseline arterial blood saturation (SpO2), haemoglobin concentration (Hgb), estimated arterial saturation (SaCO2), arterial oxygen partial pressure (PaO2) were obtained through arterial blood gas analysis, and true arterial saturation (ScoO2) through CO-Oximetry analysis. The subsequent values obtained at various points of time following the intra-arterial administration of PB were compared with the baseline data. Results: The SpO2 readings taken after intra-arterial injection of PB were significantly lower than the baseline reading. The extent of the reduction of SpO2 readings two hours after the administration of PB was relevant to the total accumulative dosage of PB (rs = -0.846, P < 0.05). However, the reduction of SpO2 bore no significant relation with Hgb concentration or with the ratio of PB dosage to Hgb concentration. Conclusions: Intra-arterial administration of PB interferes with pulse oximetry readings and the effect lasts for a variable duration. The extent of desaturation may be related to the total accumulative dosage of intra-arterial PB injected.