攝護腺癌引起骨頭疼痛的處理

Management of Prostate Cancer-Induced bone pain

腫瘤骨轉移造成骨骼疼痛是常見的，而且具有挑戰性的治療。前列腺癌具有轉移到骨的高傾向。當惡性腫瘤侵襲的骨架，會造成轉移性骨破壞，疼痛會導致發病率的增加和生活品質的下降以及骨頭骨折或其它骨相關事件的發生。雖然臨床上有多種藥物可以使用，但在效果上仍有其限制。如何緩解骨頭轉移病人的疼痛是很重要的骨頭疼痛因骨轉移造成，涉及許多原因及多模式的治療方法，包括止痛劑的臨床管理、放射療法、放射性同位素、癌症化療劑和雙膦酸鹽的治療。如何使用藥物應根據病人的臨床狀況，預期壽命，和生活品質的提昇來做綜合的考量。

Cancer induced bone pain is common and challenging to treatment. Prostate cancer has a high tendency for metastasis to bone. Malignant invasion of the skeleton, metastatic bone destruction leads to increased morbidity and impaired quality of life as a result of pain, fractures and other skeletal related events. Although there are a variety of drugs, but there are still limits its clinical. How to relieve the patient's pain due to bone metastasis is important. Clinical management of bone pain due to bone metastasis involving use of a multimodal treatment approach comprising analgesic agents (opioids, NSAIDs), radiotherapy, radioisotopes, cancer chemotherapy agents and bisphosphonates. The treatment should be individualized according to the patient's clinical condition, life expectancy, and quality of life.