台灣乳癌病患對於使用Taxane造成神經性疼痛的概況

Taxanes and Neuropathic Pain in Taiwan Breast Cancer Patients

本研究藉由健保資料庫的百萬人抽樣調查檔來檢視使用taxanes類作為乳癌化學治療藥物，病患因而產生神經性疼痛的概況，同時蒐集病患在止痛類藥物以及安眠藥的使用情形，分析並了解taxane藥物對於乳癌病人造成的影響。

Taxanes, docetaxel and paclitaxel are anticancer agents widely used for breast cancer treatment. The toxicity and neuropathic pain of paclitaxel are well discussed in the literatures; less research focus on docetaxel. Material and Method: We enrolled patients newly diagnosed breast cancer from 1 million insured sampling of National Health Insurance claim database from January Key Words: 1998 to December 2006. Patients are divided into four groups: docetaxel (d), paclitaxel Taxane, neuropathic pain, (p), both (d+p), none (n). Diagnosis of neuropathic pain and the usage of analgesics breast cancer and hypnotics were recorded and analyzed. Results: Both groups were found to have significant incidence of neuropathic pain. Docetaxel group demonstrated significant usage of analgesics and hypnotics. Conclusion: The toxicity of docetaxel may be underestimated. Remind the occurrence of neuropathic pain while using the protocol of combination of two taxanes