The purpose of the study was to identify caregivers' perception of quality of life during hospitalization of newly diagnosed leukemia children. A qualitative design was adopted. The researcher collected data through semi-structured interviews when leukemia children were hospitalized and receiving cancer chemotherapy. The first author interviewed caregivers at the pediatric unit of a university hospital. After each interview, the process recordings were recorded retrospectively and analyzed according to the principles of content analysis described by Chao et al. (1991). The findings indicated that caregivers went through a trajectory of shock, denial, uncertainty, and adjustment. Their perceptions of quality of life were identified as: (1) sleep disturbance and poor physical status; (2) uncertainty about the child's condition, fear of recurrence, and dependence on belief and religious explanation of the disease; (3) decreasing social activities and inability to care for other family members; (4) irregular life style, financial burden, and decreasing leisure time. The findings of this study may help health workers further understand perceptions of quality of life in caregivers of newly diagnosed leukemia children.