肝炎常用中藥之現代藥理機轉文獻回顧

A Review of Chinese Herbal Medicines Used for Hepatitis

台灣的肝炎盛行率非常高，肝炎造成的傷害會變成肝纖維化，而導致肝硬化，中藥常用來治療肝病，因此找尋有效的成分是中醫藥研究的方向，利用天然藥物學、分子生物學的技術，希望能夠從天然藥物中篩選出有效的抗肝炎成分。本文探討常見肝炎治病的中西醫病因，並回顧文獻探討臨床常用治療肝炎中藥之機轉，發現丹參、黃耆、大黃、黃芩等藥物，可以抗肝炎病毒，透過不同的機轉來抑制病毒，如：抑制病毒的複製、控制細胞凋亡、提升免疫力來達到療效，有些藥物尚有改善肝功能、抗肝纖維化等功效。

Taiwan have very high rates of hepatitis and the inflammation and damage can cause fibrosis, which eventually can lead to cirrhosis. Traditional Chinese medicine is commonly used in treating liver diseases. It is important that the challenge to find effective components in traditional chinese medical. By using the technology of natural medicine and molecular biology, the ingredients of natural medicine can be selected in curing heptitis. In this paper, we discuss the common causes of hepatitis treatment in Western and Chinese medicine. Also, we review several research papers about mechanisms of Chinese herbal medicines used in treatment of hepatitis, such as Salvia, Astragalus, rhubarb and skullcap. All of them can be anti-hepatitis virus by different mechanisms to inhibit viral transfer, such as inhibition of viral replication, control apoptosis, boost the immune system to achieve a therapeutic effect,and individually may have the effects of improving liver function, hepatic fibrosis for treating heptitis.