中藥濃縮製劑濃縮倍數之研究

STUDIES ON THE RELATIONSHIP BETWEEN THE CRUDE DRUGS AND EXTRACT IN THE PRESCRIPTIONS OF TRADITIONAL CHINESE MEDICINE

本研究探討水抽提物量高之處方如百合固金湯、甘露飲、地黃飲、大秦艽湯、滋燥養榮湯、活血潤燥生津飲等六個處方，其藥材之總量與乾浸膏之比例（濃縮倍數）分別為1.93：1、2.92：1、3.10：1、3~75：1、2.62：1及2.53：1。即濃縮倍數均不在規定之5～10倍之範圍內。上述處方分別以乾浸膏與澱粉以1：1、1.5：1、2：1之比例造粒，除活血潤燥生津飲外，均可完成造粒，惟由其顆粒之緊密度與安息角之測定值顯示，其流動性不佳。但另抽購其他方劑其顆粒之安息角之測定值亦呈類之流動性。

Six high water-soluble extract-containing prescriptions, such as Bae-HerGuh-Jin-Tang (百合固金湯), Gan-LuhYiin (甘露飲), Dih-Hwany-Yiin (地黃飲), Dah-Chyn-jiau-Tang (大蓁艽湯), Tzy-Tzaw-Yeang-Rong-Tang (滋燥養榮湯), Hwo-Shiueh-Ruenn-Tzaw-Sheng-jinYiin (活血潤燥生津飲) were studied. The concentration ratios of the total wights of the component crude drugs and their extracts were 1.93: 1, 2.92 : 1, 3.10 : 1, 3.75 : 1, 2.62 : 1 and 2.53 : 1 respectively, all of those were beyond the criteria of the ratio 5 to 10. Granulation of the prescriptions metioned aboved except Hwo-Shiueh-Ruenn-Tzaw- Sheng-Jin-Yiin (活血潤生津飲) Could be made with starch in a ratio of 1 : 1, 1.5 : 1, 2 : 1, From the •values of compressibilities and angel of repose for all the granules thus obtained, poor fluidities were shown.